David Ezekiel Henderson (September 3, 1879 – July 25, 1968) was a United States federal judge.
Born in Deppe, North Carolina, Henderson attended the University of North Carolina at Chapel Hill and read law in 1905. He was in private practice in New Bern, North Carolina from 1905 to 1918, and then in Charlotte, North Carolina from 1918 to 1945. He was the U.S. Attorney for the Western District of North Carolina from 1945 to 1948.
Henderson was a federal judge for. On September 1, 1948, Henderson received a recess appointment from President Harry S. Truman to a seat on the United States District Court for the Western District of North Carolina vacated by Edwin Y. Webb. Henderson's service was terminated on February 14, 1949, due to his resignation; the nomination was not considered by the United States Senate. He returned to private practice in Charlotte until his death, in 1968.